Blar i forfatter "Berzaghi, Rodrigo"

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    • Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation 

      Berzaghi, Rodrigo; Akhtar, Muhammad Asad; Islam, Md Ashraful; Pedersen, Brede Dille; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-05-17)
      The abilities of cancer-associated fibroblasts (CAFs) to regulate immune responses in the context of radiotherapy remain largely unknown. This study was undertaken to determine whether ionizing radiation alters the CAF-mediated immunoregulatory effects on macrophages. CAFs were isolated from freshly-resected non-small cell lung cancer tumors, while monocyte-derived macrophages were prepared from ...

    • Glioblastoma PET/MRI: kinetic investigation of [<sup>18</sup>F]rhPSMA-7.3, [<sup>18</sup>F]FET and [<sup>18</sup>F]fluciclovine in an orthotopic mouse model of cancer 

      Lindemann, Marcel; Oteiza, Ana; Martin-Armas, Montserrat; Guttormsen, Yngve; Moldes-Anaya, Angel; Berzaghi, Rodrigo; Bogsrud, Trond; Bach-Gansmo, Tore; Sundset, Rune; Kranz, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)
      <b><p>Purpose</b> Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [<sup>18</sup>F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare ...

    • Immunobiology of cancer-associated fibroblasts in the context of radiotherapy 

      Hellevik, Turid; Berzaghi, Rodrigo; Lode, Kristin; Islam, Md Ashraful; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-18)
      Radiotherapy (RT) still represents a mainstay of treatment in clinical oncology. Traditionally, the effectiveness of radiotherapy has been attributed to the killing potential of ionizing radiation (IR) over malignant cells, however, it has become clear that therapeutic efficacy of RT also involves activation of innate and adaptive anti-tumor immune responses. Therapeutic irradiation of the tumor ...

    • Ionizing radiation curtails immunosuppressive effects from cancer-associated fibroblasts on dendritic cells 

      Berzaghi, Rodrigo; Tornaas, Stian; Lode, Kristin; Hellevik, Turid; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Cancer-associated fibroblasts (CAFs) participate actively in tumor development and affect treatment responses, by among other mechanisms, promoting an immunosuppressive tumor microenvironment. In contrast to normal fibroblasts, reactive CAFs secrete a myriad of immunomodulatory soluble factors at high levels, i.e. growth factors, cytokines, and chemokines, which directly influence tumor immunity and ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over natural killer cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over NK cells 

      Yang, Nannan; Lode, Kristin; Berzaghi, Rodrigo; Islam, Md Ashraful; Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel, 2021-01-22)
      Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ...

    • Radiation-induced effects on TGF-beta and PDGF receptor signaling in cancer-associated fibroblasts 

      Yang, Nannan; Hellevik, Turid; Berzaghi, Rodrigo; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-15)
      Background - Cancer-associated fibroblasts (CAFs) consist of heterogeneous connective tissue cells and are often constituting the most abundant cell type in the tumor stroma. Radiation effects on tumor stromal components like CAFs in the context of radiation treatment is not well-described.<p> <p>Aim - This study explores potential changes induced by ionizing radiation (IR) on platelet-derived ...

    • Secretion rates and protein composition of extracellular vesicles released by cancer-associated fibroblasts after radiation 

      Berzaghi, Rodrigo; Islam, Md Ashraful; Hellevik, Turid; Martinez-Zubiaurre, Inigo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-24)
      Reciprocal communication between the malignant and non-malignant cellular elements in tumors is essential for cancer sustainability and plays an important role in the response of cancers to treatments. Some of this cellular crosstalk takes place via secretion of vesicles that are actively released into the extracellular space by most cell types in tumors. Recent studies have demonstrated radiation-induced ...